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GAO-21-271SP 1 (2020-12-21)

handle is hein.gao/gaobaecen0001 and id is 1 raw text is: 
                           Science,  Technology   Assessment,
                           and  Analytics




SCIENCE & TECH SPOTLIGHT:

TRACING THE SOURCE

OF CHEMICAL WEAPONS


/// THE TECHNOLOGY

What  is it? According to the Global Public Policy Institute, there have
been more than 330 chemical weapons  attacks since 2012. Such attacks
are prohibited under the Chemical Weapons Convention. A set of methods
called forensic chemical attribution has the potential to trace the chemical
agent used in such attacks to a source. For example, investigators could
use these methods to identify the geographic sources of raw materials
used to make the agent, or to identify the manufacturing process. Such
information can aid leaders in deciding on whether or how to respond to a
chemical weapons  attack.









Sample  collection    Analysis and      Source attribution
and preparation   identification
Sources (left to right): kaninstudio/stock.adobe.com; Sodel Vladyslav/stock.adobe.com;
GAO illustration. I GAO-21-271SP



How  does it work? Forensic chemical attribution is a three-step process,
though the third step is being developed (see Fig. 1). First, a sample is
taken from a victim or the site of an attack. Second, the sample's chemical
components  are analyzed and identified (see Fig. 2) either at a mobile
lab or at one of 18 authorized biomedical labs worldwide. Common
identification methods are:

  *  Gas chromatography, which separates chemical components  of a
     mixture and quantifies the amount of each chemical.
  *  Mass  spectrometry, which measures the mass-to-charge ratio of
     ions (i.e., charged particles) by converting molecules to ions and
     separating the ions based on their molecular weight.
  *  Nuclear magnetic resonance (NMR), which can determine the
     structure of a molecule by measuring the interaction between atomic
     nuclei placed in a magnetic field and exposed to radio waves. NMR
     is the same principle as magnetic resonance imaging (MRI), used in
     medical diagnostics.

In the third step-still under development-investigators use the data from
the forensic chemical identification and analysis methods from step two


to develop a chemical fingerprint. The fingerprint can be matched to a
database of information on existing methods or known source to identify
chemical agents (i.e., Source A matching Sample 1 of Fig. 2). However,
a comprehensive database containing complete, reliable data for known
agents does not exist.

How  mature  is it? Forensic chemical analysis and identification (i.e.,
Step 2 of Fig. 1) is mature for known chemical agents. For example,
investigators determined the nerve agent sarin was used in an attack on
civilians in 2017. The methods can also identify new agents, as when
investigators determined the chemical composition of the Novichok nerve
agent after its first known use in 2018.

Forensic chemical analysis and identification methods are also mature
enough  to generate data that investigators could use as a chemical
fingerprint' - that is, a unique chemical signature that could be used in
part to attribute a chemical weapon to a person or entity. For example,
combining gas chromatography  and mass spectrometry can provide
reliable information about the chemical components and molecular weight
of an agent. To achieve Step 3, scientists could use these methods in a
laboratory experiment to match impurities in chemical feedstocks of the
weapon  to potentially determine who made it. In an investigation, such
impurities could indicate the geographic origin of the starting material and
the process used to create the agent.


                             Sample identification and analysis


Sample  1


I


Sample 1


I


---      -     ~ a- I - -
                                   Source A



                                   Source B



                                   Source C


Source: GAO. I GAO-21-271SP


GAO-21-271SP Tracing the Source of Chemical Weapons

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