![handle is hein.journals/injlegame98 and id is 1 raw text is: Zeitschrift fur
Z Rechtsmed (1987) 98:1-10 Rechtsmedizin
© Springer-Verlag 1987
Originalarbeiten / Original Works
Positive and Negative Ion Mass Spectrometry
of Benzophenones, the Acid-Hydrolysis Products
of Benzodiazepines
O. Suzukil, H. Hattoriz, M. Asanol, T. Takahashi3, and H. Brandenberger4
1Department of Legal Medicine, Hamamatsu University School of Medicine,
3600 Handa-cho, Hamamatsu 431-31, Japan
2Department of Legal Medicine, Aichi Medical University,
Nagakute-cho, Aichi 480-11, Japan
3Equipment Center, Hamamatsu University School of Medicine,
3600 Hando-cho, Hamamatsu 431-31, Japan
4Department of Forensic Chemistry, University of ZUrich,
Zttrichbergstr. 8, CH-8028 Zurich, Switzerland
Summary. Positive electron impact (EI), positive chemical ionization (CI),
and negative CI mass spectra of 14 benzophenones are presented. In the
positive EI mode, intense molecular peaks appeared for most compounds;
some other peaks due to splitting at both sides of the carbonyl group also ap-
peared. In the positive CI mode, [M + 1]+ quasi-molecular ions together
with [M + C2HS]+ peaks were observed for all compounds; some fragment
peaks were common to those in the positive EI mode. In the negative CI
mode, the spectra were much simpler than those in the positive EI or CI
mode. In the 1 Torr negative CI mode, some spectra showed only single
molecular anions; in the 0.01 Torr negative CI mode, halogen or nitro peaks
appeared in addition to the molecular anions. An extraction procedure for
benzophenones from human urine and plasma after heating in strong acid,
and their separation by gas chromatography (GC) are also presented to
serve for their actual identification by GC/mass spectrometry.
Key words: Benzophenones, mass spectrometry - Mass spectrometry, nega-
tive ion chemical ionization - Benzodiazepines, mass spectrometry
Zusammenfassung: Es werden positive ElektronenstoB-(EI)-, positive che-
mische Ionisierungs-(CI)- und negative CI-Massenspektren von Benzo-
phenonderivaten beschrieben. Beim positiven EI-Modus wurden bei fast al-
len Verbindungen intensive Molekiilpeaks beobachtet; andere Peaks ent-
stehen durch Spaltungsreaktionen beiderseits der Carbonylgruppe. Beim
positiven CI-Modus erschienen quasi-molekulare Ionen [M + 1]+ zusammen
mit [M + C2HS]-Peaks bei fast allen Verbindungen; einige Fragmentierungs-
Offprint requests to: O. Suzuki (address see above)](ViewImageLocal?handle=hein.journals/injlegame98&div=1&collection=&method=preview&ext=.png&size=3)
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