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RCED-00-246R 1 (2000-07-28)

handle is hein.gao/gaocrptamac0001 and id is 1 raw text is: I GAO Accountability * Integrity * Reliability United States General Accounting Office Resources, Community, and Washington, DC 20548 Economic Development Division B-285796 July 28, 2000 The Honorable George P. Radanovich House of Representatives The Honorable Mike Thompson House of Representatives Subject: National Toxicology Program: Procedures Were Followed in Listing Alcoholic Beverage Consumption as a Known Carcinogen Each year, Americans consume significant quantities of alcoholic beverages, including beer, spirits, and wine. In 1997, sales of these beverages amounted to about $70 billion. While light to moderate use of alcoholic beverages could offer potential health benefits, such as possible cardiovascular benefits, high levels of consumption could create a number of health problems, such as liver damage and a variety of cancers. In 1978, the Secretary of Health and Human Services established the National Toxicology Program (NTP) to provide information to health regulatory and research agencies, scientific and medical communities, and the public about potentially toxic substances. NTP is required to issue a biennial report listing all substances that are either known to be carcinogens in humans or may reasonably be anticipated to be human carcinogens and to which a significant number of people residing in the United States are exposed. In this regard, NTP recently concluded that alcoholic beverage consumption is a known human carcinogen, particularly at the highest levels of consumption' and when used in conjunction with smoking.2 Concerned about whether NTP, in deciding to list alcoholic beverage consumption as a known carcinogen, adequately considered all available scientific studies, provided opportunities for public comment, and followed its standard voting procedures of straight majority rule, you asked us to examine NTP's listing procedures, including whether they were consistently applied to the review of alcoholic beverages. Specifically, you asked us to * identify the procedures NTP uses to list a substance as either a known or a reasonably anticipated human carcinogen and * determine whether NTP followed its procedures in determining to list alcoholic beverage consumption as a known human carcinogen. The report did not define the highest levels of consumption. 29' Report on Carcinogens, May 2000. GAO/RCED-00-246R National Toxicology Program

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