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Pharmaceutical R&D and the Evolving Market for Prescription Drugs 1 (October 2009)

handle is hein.congrec/cbo10104 and id is 1 raw text is: A series ofissue summaries from
the Congressional Budget Office
OCTOBER 26, 2009

Pharmaceutical R&D and the Evolving
Market for Prescription Drugs

Investment in research and development (R&D) over the
past several decades has produced a wealth of valuable
new drug therapies that have made it possible to treat
major illnesses that were not treated previously or were
not treated as effectively. As the scope of available drug
therapies expanded, spending on prescription drugs
became the fastest-growing category of total spending on
health care in the United States. Between 1994 and 2004,
real (inflation-adjusted) spending on prescription drugs
rose at an average annual rate of 11.1 percent, compared
with 3.5 percent for hospital care and 4.3 percent for
physicians' services. More recently, however, that growth
has slowed: From 2004 to 2007, drug expenditures grew
by an average of just 3.2 percent per year, slightly less
than the rate of growth in overall health care spending. As
a fraction of total spending on health care, spending on
prescription drugs rose from 6 percent in 1994 to around
11 percent in 2004, where it has remained (see Figure 1).
That slowdown in the rate of growth in spending reflects
changes in both the supply of and the demand for pre-
scription drugs. On the supply side, the patents for many
top-selling drugs have expired, subjecting them to com-
petition from cheaper generic compounds. The resulting
decline in spending on those drugs has not been fully
offset by added spending on new brand-name drugs
because, at the same time, the rate at which new drugs are
being introduced has slowed substantially. On the
demand side, many health plans have sought to control
the growth in their expenditures by creating stronger
incentives for their enrollees to choose generic drugs or
cheaper brand-name drugs.
Decisions regarding pharmaceutical R&D depend largely
on drug manufacturers' expectations about future reve-
nues. Expectations about revenues are shaped by the con-
ditions affecting the potential demand for each drug,
such as the size of its market, its price, and the amount of

competition expected from other drugs. The greater the
expected revenue from a prospective new drug, the more
willing a drugmaker will be to invest to develop it. Those
decisions will help determine which drug therapies
become available in the future and thus will affect future
growth in health care costs. This brief describes the cur-
rent state of investment in drug R&D and the factors
that influence it. It also examines how various policy
options to control the growth in health care costs or to
expand insurance coverage could affect R&D spending.
Figure 1.
Spending on Prescription Drugs as a
Percentage of Total Spending on
Health Services and Supplies,
1980 to 2007
(Percent)
12
10
8
6
4
2
0       Il
1980 1983 1986 1989 1992 1995 1998 2001 2004 2007
Source: Congressional Budget Office based on data on spending
for health services and supplies, as defined in the national
health expenditure accounts, maintained by the Centers
for Medicare and Medicaid Services.

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