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30 Animal Welfare Inst. Q. 1 (1981-1982)

handle is hein.animal/awiqu0030 and id is 1 raw text is: 





INFORMATION




REPORT


ANIMAL WELFARE INSTITUTE

P.O. Box 3650 Washington, D.C. 20007                     Spring 1981                      Vol. 30, No. 1

NIH symposium examines alternatives to animal testing


Laboratory animals: a turning point?


Trends in Bioassay Methodology in vivo, in vitro, and Mathemat-
ical Approaches. This title of a 3-day symposium sponsored by
the National Institutes of Health may not exactly set the pulses
racing but what the meeting was concerned with was ways of
reducing dependency on live animals in the testing of products.
And what emerged during these three days in February was cer-
tainly exciting and just might prove a turning point.


  The citadel of animal testing was
roundly assailed by a host of scientists
armed with the highest credentials.
Those under attack- representatives
of the chemical industry and research
and testing bodies- countered that
-substitutes will evolve, developments
cannot be legislated, money will not
buy a solution, but the citadel no
longer appears impregnable.
  Follow-up measures are already in
train. At the end of the seminar Dr
William Raub, Associate Director of
NIH, announced:
  1) The setting up of a forum con-
cerned with testing and with the ques-
tions- what are we trying to measure?
Why? At what cost in time, money and
animal lives? The forum will include
representatives of all the parties con-
cerned-federal agencies, manufac-
turers, labor unions, advocates of
rights of animals, of consumer protec-
tion and of safety in the work place.
  2) The recommendation that re-
search and regulatory agencies focus
their attention on the three Rs-
replacement, reduction and refine-
ment.
  3) The request by NIH that existing
guidelines on the treatment of (in par-
ticular) chimpanzees be modelled on
the treatment of human subjects in
experiments-in line with the new


biology adumbrated by Dr Prince dur-
ing the seminar. The thread of life as
captured in DNA is showing a pro-
found similarity in all life forms said
Dr Raub. Ten years from now our
views on ethics will be labelled biologi-
cally naive.
Salient points
  Scientific, humane, economic and
legislative factors were all amply cover-
ed during the seminar. In his opening
remarks Congressman George Brown
(D., Ca.) said that while respect for life
is on the increase, pieces of legislation
that purport to set policy don't neces-
sarily solve the problem too well. In
response to a question by Henry Spira
the Congressman said he would be


pleased if the conference would re-
commend appropriations for a pro-
gram to pursue the valid goal of al-
ternatives to animal testing.
  Dr Victor Morganroth of the Food
and Drug Administration is Chairman
of the government Interagency Regu-
latory Liaison Group which has work-
ed for four years to harmonize the
maze of regulations issued by different
agencies. In this regulatory night-
mare the agencies sometimes call for
the same animal tests resulting in an
enormous waste of animal re-
sources. Noting that to repeat the
Draize eye test on six animals costs
from $15,000 to $18,000, Dr Morgan-
roth said, Once you put a procedure
down on paper it tends to go on for
ever. Our committee is trying to adopt
the draft guidelines of the Organization
for European Community Develop-
ment. OECD recommends that: a
local anesthetic be given when a sub-
stance might cause pain; a known cor-
rosive or strong irritant not be tested in
rabbits' eyes; three animals be used in
                 Continued page 8


The Draize test- a rabbit's eye before irritant testing, and then afterwards.


/I

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