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71 Z. Rechtsmedizin 1 (1972-1973)

handle is hein.journals/injlegame71 and id is 1 raw text is: Z. Rechtsmedizin 71, 1--16 (1972) © by Springer-Verlag 1972 Ubersichtsreferat-Review Article Altersbestimmung von Verletzungen innerer Organe* GthNTHER BENEKE Abteilung Pathologic II des Zentrums fur Biologie und Theoretische Medizin der Universitit Ulm (BRD) Eingegangen am 13. Dezember 1971 Age-Determination of Injuries of Internal Organs Summary. Age-determination of injuries of internal organs is of great practical importance in forensic medicine. In most instances these investigations are performed on cadaver material. Environmental conditions for the cadavers and the post mortem interval are different from one case to another. The use of modern morphological methods, such as histochemical enzyme methods or autoradiography are therefore impossible for the determination of age of a tissue injury. Light microscopy must consequently be used for age-determination of injuries. The various stages of the reparative process must be recognized for this method of evaluation. Three general reactions are significant in this process: 1. the degenerative changes of the injured cells, 2. the local reaction of the blood circulation and 3. the reactions of non-injured parenchyma and connective tissue cells in proximity of the injury. The time relationship of these reactions can only be studied in experimental animals. The results of such experiments indicate that time relationship of cellular reactions vary with many conditions. For instance, delay of cellular repair is observed in animals which are injured before or during starvation or hemorrhagic shock. The cellular reaction is also diminished in older animals. Results obtained from animal experiments may only be applied to humans with extreme caution. The histological parameter of injury to adipose tissue, liver and kidney is demonstrated. The following parameters are of importance. The presence of necrosis or fatty degeneration of the damaged cells, the appearance of polymorphnucleated leucocytes, the appearance of iron- pigment, changes in the size of nuclei and mitoses in the parenchymatous and connective tissue cells in proximity of the injury indicating proliferation, the appearance of new-formed mucopolysaccharides, collagen and elastic fibers. Cellular repair reaction is especially depen- dent on the extent of the injury. It is impossible to use only one of these histological criteria. As many as possible of these criteria must be compared and correlated with the conditions under which the injury was inflicted. Zusammenjassung. Fur die Altersbestimmung der Verletzungen von inneren Organen stehen, im Gegensatz zu den ausgedehnt untersuchten Hautverletzungen, heute immer noch im wesentlichen nur lichtmikroskopisch nachweisbare Parameter zur Verfilgung, da sich eine Reihe moderner zellbiologischer Methoden fur den Einsatz am menschlichen Leichenmaterial nicht eignen. Um eine Altersbestimmung von Verletzungen vornehmen zu kinnen, ist die genaue Kenntnis des zeitlichen Ablaufs der Reparationsvorginge notwendig, der nur in tier- experimentellen Serienuntersuchungen zu ermitteln ist. Es ist jeweils die Prfung notwendig, inwieweit dieser experimentell ermittelte Reparationsablauf mit jenen Reparationsvorgangen zeitlich korrelierbar ist, die durch Untersuchungen von Verletzungen der inneren Organe des Menschen bekanntgeworden sind. Keinesfalls konnen die tierexperimentell ermittelten zeit- * Referat auf der 50. Jahrestagung der Gesellschaft fnr Rechtsmedizin, 3.-7. 10. 1971 in Koln. 1 Z. Rechtsmedizin 71

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