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Updated February 20, 2024


China Primer: Illicit Fentanyl and China's Role


In addressing the international dimension of the opioid
crisis in the United States, policymakers have sought to stop
foreign-sourced fentanyl, fentanyl-related substances (i.e.,
analogues), and chemical inputs (e.g., precursors) from
entering the United States. Beginning in the mid-2010s,
U.S. authorities identified the People's Republic of China
(PRC, or China) as a primary source of U.S.-bound illicit
fentanyl and fentanyl analogues. The PRC's imposition of
class-wide controls over all fentanyl-related substances in
2019 changed trafficking patterns. Direct flows of such
substances from China to the United States appeared largely
to cease. Today, the focus of China-related U.S.
counternarcotics policy has shifted to preventing PRC-
sourced fentanyl precursors and associated equipment,
along with other synthetic drugs that may be mixed with
fentanyl substances, from entering the U.S.-bound fentanyl
supply chain. The U.S. government also seeks to target
illicit fentanyl-related financial flows linked to China. A
November  2023  summit in California between President
Joseph R. Biden Jr. and China's leader, Xi Jinping, renewed
cooperation on drug control issues after more than three
years of stasis.
Background
Fentanyl is a potent synthetic opioid that has been used
medically as a painkiller and an anesthetic since it was first
synthesized in 1959. Due to fentanyl's potential for abuse
and addiction, the United Nations (U.N.) placed it under
international control in 1964. Domestically, fentanyl is
regulated by the Drug Enforcement Administration (DEA),
pursuant to the Comprehensive Drug Abuse Prevention and
Control Act of 1970, as amended (21 U.S.C. §§801 et seq.).
The U.S. Centers for Disease Control and Prevention
estimate that synthetic opioids (primarily fentanyl-related
substances) may have resulted in more than 78,000 U.S.
overdose deaths between September 2022 and August 2023.
Traffickers appear to be marketing a growing number of
fentanyl analogues for nonmedical, often unregulated, use.
As of November  2023, the International Narcotics Control
Board (INCB)-an   independent expert body that monitors
governments' compliance with U.N. drug control
conventions-reported  the existence of 153 fentanyl-related
substances with no currently known legitimate uses. The
U.N. Office on Drugs and Crime estimates that laboratories
could potentially synthesize thousands of other fentanyl
analogues. As of May 2023, more than 30 fentanyl-related
substances, including precursors, are subject to international
control (scheduled) pursuant to the U.N. Single
Convention on Narcotic Drugs of 1961, as amended, and
the U.N. Convention Against Illicit Traffic in Narcotic
Drugs and Psychotropic Substances of 1988.
U.N. member  states first subjected fentanyl precursors to
international control in 2017, agreeing to list the precursors
N-Phenethyl-4-piperidone (NPP) and 4-Anilino-N-
phenethylpiperidine (ANPP) on Table I of the 1988


Convention. In 2018, consistent with the U.N. decision, the
PRC  implemented  corresponding domestic controls. In
2022, U.N. member  states subjected three additional
fentanyl precursors to international control: N-Phenyl-4-
piperidinamine (4-AP), tert-Butyl 4-(phenylamino)
piperidine-1-carboxylate (1-boc-4-AP), and norfentanyl. In
June 2023, the PRC government said it was in the process
of scheduling three additional fentanyl precursors-
presumably those the U.N. scheduled in 2022-but the PRC
has provided no further information.

Sources and Trafficking Pathways
DEA  alleges that PRC-based chemical companies advertise
and sell online fentanyl precursor chemicals, including
some  that are not internationally controlled and are
correspondingly legal to export out of China. PRC firms
also sell other synthetic drugs of concern, including
xylazine and nitazenes. PRC companies ship such items to
Mexico  or directly to the United States, including via the
U.S. Postal Service and express consignment services,
carefully packaged to deceive customs inspectors.
According to DEA,  customers, often associated with
Mexico-based  transnational criminal organizations (TCOs),
may  pay for the chemicals and drugs in cryptocurrencies,
making  it harder for DEA to follow the money. They also
pay using U.S. and PRC payment services or bank transfers.
DEA  alleges that the TCOs use largely PRC-sourced
chemicals to synthesize fentanyl substances in clandestine
laboratories, and often mix xylazine and nitazenes into
fentanyl-related products, making the substances even
deadlier, before distributing them across North America.
The 2022 report of the U.S. Commission on Combating
Synthetic Opioid Trafficking (established pursuant to §7221
of P.L. 116-92) concluded that the PRC's chemical and
pharmaceutical sectors have outpaced the government's
efforts to regulate them, creating opportunities for
unscrupulous vendors to export chemicals needed in their
illegal manufacture. The U.S. Department of the Treasury
assesses that Mexico-based cartels are increasingly working
with PRC  money laundering organizations.
Add   ressing   China's Role
The Biden Administration's 2022 National Drug Control
Strategy prioritizes increased collaboration with the PRC
on shared drug priorities and continued engagement to
reduce diversion of uncontrolled precursor chemicals. In
February 2023 Senate testimony, Assistant Secretary of
State for International Narcotics and Law Enforcement
Affairs Todd Robinson noted that the United States has
encouraged the PRC to improve information-sharing on
global chemical flows, strengthen enforcement of customs
manifesting agreements, and implement know-your-
customer standards to restrict the sale of precursor
chemicals to only customers with legitimate needs. In July

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