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Congres &onaI Research Se
informing Ih  legislative debat s in e 1914


Updated February 13, 2024


China Primer: Illicit Fentanyl and China's Role


In the context of the ongoing opioid crisis in the United
States, illicit fentanyl is both a domestic and a foreign
policy issue for Congress. In addressing the international
dimension, policymakers have endeavored to stop foreign-
sourced fentanyl, fentanyl-related substances (i.e.,
analogues), and chemical inputs (i.e., precursors) from
entering the United States. Early in the rise of U.S. illicit
fentanyl use, beginning in the mid-2010s, U.S. authorities
identified the People's Republic of China (PRC, or China)
as the primary source of illicit fentanyl entering the United
States. Since 2019, direct flows appear to have largely
ceased. The focus of U.S. counternarcotics policy with
regard to China has shifted to preventing PRC-sourced
fentanyl precursors, along with manufactured or synthetic
drugs often mixed with fentanyl substances, from entering
the U.S.-bound fentanyl supply chain. The U.S. government
also seeks to prevent illicit exports of pill presses from the
PRC  and illicit fentanyl-related financial flows linked to
China. A November  2023 summit  in California between
President Joseph R. Biden, Jr. and China's leader, Xi
Jinping, renewed cooperation on drug control issues after
more than three years of stasis.

Background
Fentanyl is a potent synthetic opioid that has been used
medically as a painkiller and an anesthetic since it was first
synthesized in 1959. Due to fentanyl's potential for abuse
and addiction, the United Nations (U.N.) placed it under
international control in 1964. Domestically, fentanyl is
regulated by the Drug Enforcement Administration (DEA),
pursuant to the Comprehensive Drug Abuse Prevention and
Control Act of 1970, as amended (21 U.S.C. §§801 et seq.).
The U.S. Centers for Disease Control and Prevention
estimate that synthetic opioids (primarily fentanyl-related
substances) may have resulted in more than 78,000 U.S.
overdose deaths between September 2022 and August 2023.
Traffickers appear to be marketing a growing number of
fentanyl analogues for nonmedical, often unregulated, use.

As of November  2023, the International Narcotics Control
Board (INCB)-an   independent expert body that monitors
governments' compliance with U.N. drug control
conventions-reported  the existence of 153 fentanyl-related
substances with no currently-known legitimate uses. The
U.N. Office on Drugs and Crime estimates that laboratories
could potentially synthesize thousands of other fentanyl
analogues. As of May 2023, more than 30 fentanyl-related
substances, including precursors, are subject to international
control (scheduled) pursuant to the U.N. Single
Convention on Narcotic Drugs of 1961, as amended, and
the U.N. Convention Against Illicit Traffic in Narcotic
Drugs and Psychotropic Substances of 1988.

U.N. member  states first subjected fentanyl precursors to
international control in 2017, agreeing to list the precursors


N-Phenethyl-4-piperidone (NPP) and 4-Anilino-N-
phenethylpiperidine (ANPP) on Table I of the 1988
Convention. In 2018, consistent with the U.N. decision, the
PRC  implemented  corresponding domestic controls. In
2022, U.N. member  states subjected three additional
fentanyl precursors to international control: N-Phenyl-4-
piperidinamine (4-AP), tert-Butyl 4-(phenylamino)
piperidine-1-carboxylate (boc-4-AP), and norfentanyl. In
June 2023, the PRC government said it was in the process
of scheduling three additional fentanyl precursors-
presumably those the U.N. scheduled in 2022-but the PRC
has provided no further information.

Sources and Trafficking Pathways
Prior to 2019, the DEA identified China as the primary
source of U.S.-bound illicit fentanyl, fentanyl-related
substances, and production equipment. PRC traffickers
supplied fentanyl and fentanyl-related substances directly to
the United States via international mail or express
consignment operations.

Trafficking patterns changed after the PRC imposed class-
wide controls over all fentanyl-related substances in 2019.
Today, DEA  alleges that PRC-based chemical companies
advertise and sell online fentanyl precursor chemicals,
including some that are not internationally controlled and
are correspondingly legal to export out of China, as well as
manufactured or synthetic drugs such as xylazine and
nitazenes. The companies ship the items to Mexico and
directly to the United States, including via the U.S. Postal
Service and express consignment services, carefully
packaged to deceive customs inspectors. According to
DEA,  customers, often associated with Mexico-based
transnational criminal organizations (TCOs), commonly
pay for the chemicals and drugs in cryptocurrencies,
making  it harder for DEA to follow the money. They also
pay using U.S. and PRC payment services or bank transfers.
DEA  alleges that the TCOs use largely PRC-sourced
chemicals to synthesize fentanyl substances in clandestine
laboratories, and often mix xylazine and nitazenes into the
fentanyl substances, making the substances even deadlier,
before distributing them across North America.

The 2022 report of the U.S. Commission on Combating
Synthetic Opioid Trafficking (established pursuant to §7221
of P.L. 116-92) concluded that the PRC's chemical and
pharmaceutical sectors have outpaced the government's
efforts to regulate them, creating opportunities for
unscrupulous vendors to export chemicals needed in their
illegal manufacture. The U.S. Department of the Treasury
assesses that Mexico-based cartels are increasingly working
with PRC  money laundering organizations.

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