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Updated July 18, 2022

China Primer: Illicit Fentanyl and China's Role

Addressing illicit fentanyl in the context of the ongoing
opioid crisis in the United States is a domestic and foreign
policy issue for the 117th Congress. In addressing the
international dimensions of the problem, policymakers have
endeavored to stop foreign-sourced fentanyl, fentanyl-
related substances (i.e., analogues and precursor chemicals),
and emerging synthetic opioids from entering the United
States. U.S. counternarcotics policy has included a focus on
reducing fentanyl and fentanyl precursor flows from the
People's Republic of China (PRC, or China). Despite some
early successes, cooperation with the PRC appears to have
waned in recent years, consistent with an overall
deterioration in U.S.-China relations.
Background
Fentanyl is a potent synthetic opioid used medically as a
painkiller and an anesthetic since it was first synthesized in
1959. Due to fentanyl's potential for abuse and addiction,
the United Nations (U.N.) placed it under international
control in 1964. In the United States, fentanyl is regulated
by the Drug Enforcement Administration (DEA), pursuant
to the Comprehensive Drug Abuse Prevention and Control
Act of 1970, as amended (21 U.S.C. §§801 et seq.).
Fentanyl and its analogues have emerged as a major
international drug control problem. Overdose deaths from
their abuse have continued to rise in the United States, and
a growing number of fentanyl analogues appear marketed
for nonmedical, often unregulated use. As of November
2021, the International Narcotics Control Board-an
independent expert body that monitors government
compliance with international drug control treaties-
reported the existence of more than 150 fentanyl-related
substances with no currently known legitimate uses. The
U.N. Office on Drugs and Crime estimates that laboratories
could potentially synthesize thousands of other fentanyl
analogues. As of June 2022, more than 30 fentanyl-related
substances, including precursors, are scheduled for
international control pursuant to the U.N. Single
Convention on Narcotic Drugs of 1961, as amended, and
the U.N. Convention Against Illicit Traffic in Narcotic
Drugs and Psychotropic Substances of 1988.
In 2017, U.N. member states agreed to list two fentanyl
precursor chemicals on Table I of the 1988 Convention,
subjecting them for the first time to international controls:
N-phenethyl-4-piperidone (NPP) and 4-anilino-N-
phenethyl-4-piperidone (ANPP). (In February 2018,
consistent with the U.N. decision, the PRC implemented
corresponding domestic controls.) In March 2022, U.N.
member states decided to add three more fentanyl
precursors under international control: 4-anilinopiperidine
(4-AP), 1-(tert-butoxycarbonyl)-4-phenylaminopiperidine
(boc-4-AP), and N-phenyl-N-(piperidin-4-yl) propionamide
(norfentanyl).

Sources and Trafficking Pathways
While not a new phenomenon, the illicit production and
trafficking of fentanyl and fentanyl analogues in recent
years have been associated with rising numbers of U.S.
opioid-related overdose fatalities. Clandestine laboratories
may engage in illicit production of fentanyl, fentanyl
analogues, and precursors. Legitimate companies may
produce unregulated analogues and precursors, while
legally manufactured fentanyl pharmaceutical products may
be diverted through theft and fraudulent prescriptions.
In the years immediately prior to 2019, China was the
primary source of U.S.-bound illicit fentanyl, fentanyl
precursors, and production equipment. Fentanyl and
fentanyl-related substances were trafficked directly from
the PRC to the United States through international mail and
express consignment operations. Trafficking patterns have
changed since the PRC imposed class-wide controls over all
fentanyl-related substances, effective May 2019. Today,
Mexican transnational criminal organizations (TCOs) are
largely responsible for the production of U.S.-consumed
illicit fentanyl, using PRC-sourced primary materials,
including precursor chemicals that are legal to produce and
export in China. According to DEA assessments cited by
the U.S.-China Economic and Security Review
Commission, Chinese traffickers and money launderers
appear to have increased cooperation with Mexican cartels.
In February 2022, the U.S. Commission on Combating
Synthetic Opioid Trafficking, established pursuant to
Section 7221 of the National Defense Authorization Act for
Fiscal Year 2020 (P.L. 116-92), concluded that the PRC's
chemical and pharmaceutical sectors have outpaced the
government's efforts to regulate them, creating
opportunities for unscrupulous vendors to export chemicals
needed in their illegal manufacture. Moreover, the
commission found that traffickers' exploitation of existing
global logistics and trade networks (e.g., postal, courier,
and commercial cargo systems), as well as widely used
online marketing and communication platforms, including
those with encryption capabilities, challenge law
enforcement detection of fentanyl-related flows. The U.S.
Department of the Treasury's Financial Crimes
Enforcement Network has reported that traffickers also
exploit features of the dark web and cryptocurrencies to
procure and purchase fentanyl-related substances.
Add ressing Ch ina's Role
U.S. foreign policy efforts to stem the flow of illicit
fentanyl-related substances into the United States have
focused on bilateral engagement and multilateral
cooperation with entities including the United Nations and
other stakeholders on such goals as scheduling more
fentanyl analogues and precursors for drug control. Such
efforts fit within broader goals of targeting the foreign

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